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Stapled BH3 Peptides against MCL-1: Mechanism and Design Using Atomistic Simulations
Atomistic simulations of a set of stapled alpha helical peptides derived from the BH3 helix of MCL-1 (Stewart et al. (2010) Nat Chem Biol 6: 595–601) complexed to a fragment (residues 172–320) of MCL-1 revealed that the highest affinity is achieved when the staples engage the surface of MCL-1 as has...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3432064/ https://ncbi.nlm.nih.gov/pubmed/22952838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043985 |
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