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Tyrosine Residues Mediate Fibril Formation in a Dynamic Light Chain Dimer Interface
Light chain amyloidosis is an incurable protein misfolding disease where monoclonal immunoglobulin light chains misfold and deposit as amyloid fibrils, causing organ failure and death. Previously, we determined that amyloidogenic light chains AL-09 and AL-103 do not form fibrils at pH 10 (tyrosine p...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3431636/ https://ncbi.nlm.nih.gov/pubmed/22740699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.362921 |
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