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A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface

Light chain amyloidosis is a devastating protein misfolding disease characterized by the accumulation of amyloid fibrils that causes tissue damage and organ failure. These fibrils are composed of monoclonal light chain protein secreted from an abnormal proliferation of bone marrow plasma cells. We p...

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Detaylı Bibliyografya
Asıl Yazarlar: Peterson, Francis C., Baden, Elizabeth M., Owen, Barbara A. L., Volkman, Brian F., Ramirez-Alvarado, Marina
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872106/
https://ncbi.nlm.nih.gov/pubmed/20462490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.02.012
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