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Glycosaminoglycans promote fibril formation by amyloidogenic immunoglobulin light chains through a transient interaction
Amyloid formation occurs when a precursor protein misfolds and aggregates, forming a fibril nucleus that serves as a template for fibril growth. Glycosaminoglycans are highly charged polymers known to associate with tissue amyloid deposits that have been shown to accelerate amyloidogenesis in vitro....
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3133826/ https://ncbi.nlm.nih.gov/pubmed/21640469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2011.05.011 |
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