Structure of the Nuclear Factor κB-inducing Kinase (NIK) Kinase Domain Reveals a Constitutively Active Conformation

NF-κB-inducing kinase (NIK) is a central component in the non-canonical NF-κB signaling pathway. Excessive NIK activity is implicated in various disorders, such as autoimmune conditions and cancers. Here, we report the first crystal structure of truncated human NIK in complex with adenosine 5′-O-(th...

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Autores principales: Liu, Jinsong, Sudom, Athena, Min, Xiaoshan, Cao, Zhaodan, Gao, Xiong, Ayres, Merrill, Lee, Fei, Cao, Ping, Johnstone, Sheree, Plotnikova, Olga, Walker, Nigel, Chen, Guoqing, Wang, Zhulun
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431628/
https://ncbi.nlm.nih.gov/pubmed/22718757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.366658
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