Structure of the Nuclear Factor κB-inducing Kinase (NIK) Kinase Domain Reveals a Constitutively Active Conformation

NF-κB-inducing kinase (NIK) is a central component in the non-canonical NF-κB signaling pathway. Excessive NIK activity is implicated in various disorders, such as autoimmune conditions and cancers. Here, we report the first crystal structure of truncated human NIK in complex with adenosine 5′-O-(th...

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Bibliografske podrobnosti
Main Authors: Liu, Jinsong, Sudom, Athena, Min, Xiaoshan, Cao, Zhaodan, Gao, Xiong, Ayres, Merrill, Lee, Fei, Cao, Ping, Johnstone, Sheree, Plotnikova, Olga, Walker, Nigel, Chen, Guoqing, Wang, Zhulun
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431628/
https://ncbi.nlm.nih.gov/pubmed/22718757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.366658
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