An Inhibitory Antibody against Dipeptidyl Peptidase IV Improves Glucose Tolerance in Vivo

Dipeptidyl peptidase IV (DPP-IV) degrades the incretin hormone glucagon-like peptide 1 (GLP-1). Small molecule DPP-IV inhibitors have been used as treatments for type 2 diabetes to improve glucose tolerance. However, each of the marketed small molecule drugs has its own limitation in terms of effica...

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Główni autorzy: Tang, Jie, Majeti, Jiangwen, Sudom, Athena, Xiong, Yumei, Lu, Mei, Liu, Qiang, Higbee, Jared, Zhang, Yi, Wang, Yan, Wang, Wei, Cao, Ping, Xia, Zhen, Johnstone, Sheree, Min, Xiaoshan, Yang, Xiaoping, Shao, Hui, Yu, Timothy, Sharkov, Nik, Walker, Nigel, Tu, Hua, Shen, Wenyan, Wang, Zhulun
Format: Artigo
Język:Inglês
Wydane: American Society for Biochemistry and Molecular Biology 2013
Hasła przedmiotowe:
Protein Structure and Folding
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543014/
https://ncbi.nlm.nih.gov/pubmed/23184939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.396317
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