A 17-residue Sequence from the Matrix Metalloproteinase-9 (MMP-9) Hemopexin Domain Binds α4β1 Integrin and Inhibits MMP-9-induced Functions in Chronic Lymphocytic Leukemia B Cells

We previously showed that pro-matrix metalloproteinase-9 (proMMP-9) binds to B chronic lymphocytic leukemia (B-CLL) cells and contributes to B-CLL progression by regulating cell migration and survival. Induction of cell survival involves a non-proteolytic mechanism and the proMMP-9 hemopexin domain...

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Bibliografiska uppgifter
Huvudupphovsmän: Ugarte-Berzal, Estefanía, Bailón, Elvira, Amigo-Jiménez, Irene, Vituri, Cidonia L., del Cerro, Mercedes Hernández, Terol, María José, Albar, Juan P., Rivas, Germán, García-Marco, José A., García-Pardo, Angeles
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2012
Ämnen:
Molecular Bases of Disease
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431623/
https://ncbi.nlm.nih.gov/pubmed/22730324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.354670
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