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A Novel CD44-binding Peptide from the Pro-Matrix Metalloproteinase-9 Hemopexin Domain Impairs Adhesion and Migration of Chronic Lymphocytic Leukemia (CLL) Cells

(pro)MMP-9 binds to CLL cells through the PEX9 domain and contributes to CLL progression. To biochemically characterize this interaction and identify potential therapeutic targets, we prepared GST-PEX9 forms containing structural blades B1B2 or B3B4. We recently described a sequence in blade B4 (P3...

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Bibliografiske detaljer
Main Authors: Ugarte-Berzal, Estefanía, Bailón, Elvira, Amigo-Jiménez, Irene, Albar, Juan Pablo, García-Marco, José A., García-Pardo, Angeles
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140891/
https://ncbi.nlm.nih.gov/pubmed/24739387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.559187
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