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Liver Protein Targets of Hepatotoxic 4-Bromophenol Metabolites

The hepatotoxicity of bromobenzene (BB) is directly related to the covalent binding of both initially formed epoxide and secondary quinone metabolites to at least 45 different liver proteins. 4-Bromophenol (4BP) is a significant BB metabolite and a precursor to reactive quinone metabolites, yet when...

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Hlavní autoři: Koen, Yakov M., Hajovsky, Heather, Liu, Ke, Williams, Todd D., Galeva, Nadezhda A., Staudinger, Jeffrey L., Hanzlik, Robert P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431021/
https://ncbi.nlm.nih.gov/pubmed/22827705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx3002675
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