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Evolutionary History and Genome Organization of DUF1220 Protein Domains

DUF1220 protein domains exhibit the most extreme human lineage–specific (HLS) copy number increase of any protein coding region in the human genome and have recently been linked to evolutionary and pathological changes in brain size (e.g., 1q21‐associated microcephaly). These findings lend support t...

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Main Authors: O’Bleness, Majesta S., Dickens, C. Michael, Dumas, Laura J., Kehrer-Sawatzki, Hildegard, Wyckoff, Gerald J., Sikela, James M.
Formato: Artigo
Idioma:Inglês
Publicado: Genetics Society of America 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429928/
https://ncbi.nlm.nih.gov/pubmed/22973535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.112.003061
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