The in Vitro – in Vivo Translation of Lipid Nanoparticles for Hepatocellular siRNA Delivery

A significant challenge in the development of clinically-viable siRNA delivery systems is a lack of in vitro – in vivo translatability: many delivery vehicles that are initially promising in cell culture do not retain efficacy in animals. Despite its importance, little information exists on the pred...

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Bibliographic Details
Main Authors: Whitehead, Kathryn A., Matthews, Jonathan, Chang, Philip H., Niroui, Farnaz, Dorkin, J. Robert, Severgnini, Mariano, Anderson, Daniel G.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429655/
https://ncbi.nlm.nih.gov/pubmed/22770391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn301922x
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