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Selective BRAF inhibition decreases tumor-resident lymphocyte frequencies in a mouse model of human melanoma

The development of targeted therapies and immunotherapies has markedly advanced the treatment of metastasized melanoma. While treatment with selective BRAF(V600E) inhibitors (like vemurafenib or dabrafenib) leads to high response rates but short response duration, CTLA-4 blocking therapies induce su...

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Hlavní autoři: Hooijkaas, Anna, Gadiot, Jules, Morrow, Michelle, Stewart, Ross, Schumacher, Ton, Blank, Christian U.
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429565/
https://ncbi.nlm.nih.gov/pubmed/22934253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.20226
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