Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

Tissue damage causes inflammation, by recruiting leukocytes and activating them to release proinflammatory mediators. We show that high-mobility group box 1 protein (HMGB1) orchestrates both processes by switching among mutually exclusive redox states. Reduced cysteines make HMGB1 a chemoattractant,...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Venereau, Emilie, Casalgrandi, Maura, Schiraldi, Milena, Antoine, Daniel J., Cattaneo, Angela, De Marchis, Francesco, Liu, Jaron, Antonelli, Antonella, Preti, Alessandro, Raeli, Lorenzo, Shams, Sara Samadi, Yang, Huan, Varani, Luca, Andersson, Ulf, Tracey, Kevin J., Bachi, Angela, Uguccioni, Mariagrazia, Bianchi, Marco E.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2012
Sujets:
Brief Definitive Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428943/
https://ncbi.nlm.nih.gov/pubmed/22869893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120189
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires