Oxidation State Dependent Conformational Changes of HMGB1 Regulate the Formation of the CXCL12/HMGB1 Heterocomplex

High-mobility Group Box 1 (HMGB1) is an abundant protein present in all mammalian cells and involved in several processes. During inflammation or tissue damage, HMGB1 is released in the extracellular space and, depending on its redox state, can form a heterocomplex with CXCL12. The heterocomplex act...

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Detalhes bibliográficos
Publicado no:Comput Struct Biotechnol J
Main Authors: Fassi, Enrico M.A., Sgrignani, Jacopo, D'Agostino, Gianluca, Cecchinato, Valentina, Garofalo, Maura, Grazioso, Giovanni, Uguccioni, Mariagrazia, Cavalli, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: Research Network of Computational and Structural Biotechnology 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6617219/
https://ncbi.nlm.nih.gov/pubmed/31333815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2019.06.020
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