Oxidation State Dependent Conformational Changes of HMGB1 Regulate the Formation of the CXCL12/HMGB1 Heterocomplex

High-mobility Group Box 1 (HMGB1) is an abundant protein present in all mammalian cells and involved in several processes. During inflammation or tissue damage, HMGB1 is released in the extracellular space and, depending on its redox state, can form a heterocomplex with CXCL12. The heterocomplex act...

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Bibliografiska uppgifter
I publikationen:Comput Struct Biotechnol J
Huvudupphovsmän: Fassi, Enrico M.A., Sgrignani, Jacopo, D'Agostino, Gianluca, Cecchinato, Valentina, Garofalo, Maura, Grazioso, Giovanni, Uguccioni, Mariagrazia, Cavalli, Andrea
Materialtyp: Artigo
Språk:Inglês
Publicerad: Research Network of Computational and Structural Biotechnology 2019
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6617219/
https://ncbi.nlm.nih.gov/pubmed/31333815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2019.06.020
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