Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

Tissue damage causes inflammation, by recruiting leukocytes and activating them to release proinflammatory mediators. We show that high-mobility group box 1 protein (HMGB1) orchestrates both processes by switching among mutually exclusive redox states. Reduced cysteines make HMGB1 a chemoattractant,...

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Bibliografski detalji
Glavni autori: Venereau, Emilie, Casalgrandi, Maura, Schiraldi, Milena, Antoine, Daniel J., Cattaneo, Angela, De Marchis, Francesco, Liu, Jaron, Antonelli, Antonella, Preti, Alessandro, Raeli, Lorenzo, Shams, Sara Samadi, Yang, Huan, Varani, Luca, Andersson, Ulf, Tracey, Kevin J., Bachi, Angela, Uguccioni, Mariagrazia, Bianchi, Marco E.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2012
Teme:
Brief Definitive Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428943/
https://ncbi.nlm.nih.gov/pubmed/22869893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120189
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