Diflunisal targets the HMGB1/CXCL12 heterocomplex and blocks immune cell recruitment

Extracellular HMGB1 triggers inflammation following infection or injury and supports tumorigenesis in inflammation‐related malignancies. HMGB1 has several redox states: reduced HMGB1 recruits inflammatory cells to injured tissues forming a heterocomplex with CXCL12 and signaling via its receptor CXC...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: De Leo, Federica, Quilici, Giacomo, Tirone, Mario, De Marchis, Francesco, Mannella, Valeria, Zucchelli, Chiara, Preti, Alessandro, Gori, Alessandro, Casalgrandi, Maura, Mezzapelle, Rosanna, Bianchi, Marco E, Musco, Giovanna
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776901/
https://ncbi.nlm.nih.gov/pubmed/31418171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201947788
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