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Molecular cycloencapsulation augments solubility and improves therapeutic index of brominated noscapine in prostate cancer cells

We have previously shown that a novel microtubule-modulating noscapinoid, EM011 (9-Br-Nos), displays potent anticancer activity by inhibition of cellular proliferation and induction of apoptosis in prostate cancer cells and preclinical mice models. However, physicochemical and cellular barriers encu...

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Detalhes bibliográficos
Main Authors: Madan, Jitender, Baruah, Bharat, Nagaraju, Mulpuri, Abdalla, Mohamed O., Yates, Clayton, Turner, Timothy, Rangari, Vijay, Hamelberg, Donald, Aneja, Ritu
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428378/
https://ncbi.nlm.nih.gov/pubmed/22540277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp300063v
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