Cyclodextrin Complexes of Reduced Bromonoscapine in Guar Gum Microspheres Enhance Colonic Drug Delivery

[Image: see text] Here, we report improved solubility and enhanced colonic delivery of reduced bromonoscapine (Red-Br-Nos), a cyclic ether brominated analogue of noscapine, upon encapsulation of its cyclodextrin (CD) complexes in bioresponsive guar gum microspheres (GGM). Phase–solubility analysis s...

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Detalhes bibliográficos
Publicado no:Mol Pharm
Main Authors: Madan, Jitender, Gundala, Sushma R., Baruah, Bharat, Nagaraju, Mulpuri, Yates, Clayton, Turner, Timothy, Rangari, Vijay, Hamelberg, Donald, Reid, Michelle D., Aneja, Ritu
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255741/
https://ncbi.nlm.nih.gov/pubmed/25350222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp500408n
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