Influence of Methylene Blue on Microglia-Induced Inflammation and Motor Neuron Degeneration in the SOD1(G93A) Model for ALS

Mutations in SOD1 cause hereditary variants of the fatal motor neuron disease amyotrophic lateral sclerosis (ALS). Pathophysiology of the disease is non-cell-autonomous, with toxicity deriving also from glia. In particular, microglia contribute to disease progression. Methylene blue (MB) inhibits th...

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Autori principali: Dibaj, Payam, Zschüntzsch, Jana, Steffens, Heinz, Scheffel, Jörg, Göricke, Bettina, Weishaupt, Jochen H., Le Meur, Karim, Kirchhoff, Frank, Hanisch, Uwe-Karsten, Schomburg, Eike D., Neusch, Clemens
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428282/
https://ncbi.nlm.nih.gov/pubmed/22952827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043963
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