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Lack of Effect of Methylene Blue in the SOD1 G93A Mouse Model of Amyotrophic Lateral Sclerosis

BACKGROUND: Methylene blue (MB) is a drug with a long history and good safety profile, and with recently-described features desirable in a treatment for ALS. METHODOLOGY/PRINCIPAL FINDINGS: We tested oral MB in inbred high-copy number SOD1 G93A mice, at 25 mg/kg/day beginning at 45 days of age. We m...

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Detalhes bibliográficos
Main Authors: Lougheed, Rosamond, Turnbull, John
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188547/
https://ncbi.nlm.nih.gov/pubmed/21998625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023141
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