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In Vivo Imaging Reveals Distinct Inflammatory Activity of CNS Microglia versus PNS Macrophages in a Mouse Model for ALS

Mutations in the enzyme superoxide dismutase-1 (SOD1) cause hereditary variants of the fatal motor neuronal disease Amyotrophic lateral sclerosis (ALS). Pathophysiology of the disease is non-cell-autonomous: neurotoxicity is derived not only from mutant motor neurons but also from mutant neighbourin...

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Detalhes bibliográficos
Main Authors: Dibaj, Payam, Steffens, Heinz, Zschüntzsch, Jana, Nadrigny, Fabien, Schomburg, Eike D., Kirchhoff, Frank, Neusch, Clemens
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060882/
https://ncbi.nlm.nih.gov/pubmed/21437247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017910
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