ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression

Metastatic cancer is extremely difficult to treat, and the presence of metastases greatly reduces a cancer patient’s likelihood of long-term survival. The ZEB1 transcriptional repressor promotes metastasis through downregulation of microRNAs (miRs) that are strong inducers of epithelial differentiat...

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Bibliographische Detailangaben
Hauptverfasser: Ahn, Young-Ho, Gibbons, Don L., Chakravarti, Deepavali, Creighton, Chad J., Rizvi, Zain H., Adams, Henry P., Pertsemlidis, Alexander, Gregory, Philip A., Wright, Josephine A., Goodall, Gregory J., Flores, Elsa R., Kurie, Jonathan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428095/
https://ncbi.nlm.nih.gov/pubmed/22850877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63608
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