p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi

Cancer cells exhibit hyperactive secretory states that maintain cancer cell viability and remodel the tumor microenvironment. However, the oncogenic signals that heighten secretion remain unclear. Here, we show that p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi. p53 loss...

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Bibliographic Details
Published in:Sci Adv
Main Authors: Tan, Xiaochao, Banerjee, Priyam, Shi, Lei, Xiao, Guan-Yu, Rodriguez, B. Leticia, Grzeskowiak, Caitlin L., Liu, Xin, Yu, Jiang, Gibbons, Don L., Russell, William K., Creighton, Chad J., Kurie, Jonathan M.
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2021
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213221/
https://ncbi.nlm.nih.gov/pubmed/34144984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf4885
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