p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi

Cancer cells exhibit hyperactive secretory states that maintain cancer cell viability and remodel the tumor microenvironment. However, the oncogenic signals that heighten secretion remain unclear. Here, we show that p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi. p53 loss...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Tan, Xiaochao, Banerjee, Priyam, Shi, Lei, Xiao, Guan-Yu, Rodriguez, B. Leticia, Grzeskowiak, Caitlin L., Liu, Xin, Yu, Jiang, Gibbons, Don L., Russell, William K., Creighton, Chad J., Kurie, Jonathan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213221/
https://ncbi.nlm.nih.gov/pubmed/34144984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf4885
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