Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer

Cancer cells exhibit heightened secretory states that drive tumor progression. Here, we identified a chromosome 3q amplicon that serves as a platform for secretory regulation in cancer. The 3q amplicon encodes multiple Golgi-resident proteins, including the scaffold Golgi integral membrane protein 4...

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Bibliografski detalji

Glavni autori:	Xiaochao Tan, Shike Wang, Guan-Yu Xiao, Chao Wu, Xin Liu, Biyao Zhou, Yu Jiang, Dzifa Y. Duose, Yuanxin Xi, Jing Wang, Kunika Gupta, Apar Pataer, Jack A. Roth, Michael P. Kim, Fengju Chen, Chad J. Creighton, William K. Russell, Jonathan M. Kurie
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Clinical Investigation 2024-06-01
Serija:	The Journal of Clinical Investigation
Teme:	Cell biology Oncology
Online pristup:	https://doi.org/10.1172/JCI176355
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