p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi

Cancer cells exhibit hyperactive secretory states that maintain cancer cell viability and remodel the tumor microenvironment. However, the oncogenic signals that heighten secretion remain unclear. Here, we show that p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi. p53 loss...

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Detalles Bibliográficos
Publicado en:Sci Adv
Main Authors: Tan, Xiaochao, Banerjee, Priyam, Shi, Lei, Xiao, Guan-Yu, Rodriguez, B. Leticia, Grzeskowiak, Caitlin L., Liu, Xin, Yu, Jiang, Gibbons, Don L., Russell, William K., Creighton, Chad J., Kurie, Jonathan M.
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213221/
https://ncbi.nlm.nih.gov/pubmed/34144984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf4885
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