Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells

Induced pluripotent stem cells (iPSCs) can be formed from somatic cells by a defined set of genetic factors; however, aberrant epigenetic silencing of the imprinted Dlk1-Dio3 gene cluster often hinders their developmental potency and ability to contribute to high-grade chimerism in mice. Here, we de...

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Bibliografiska uppgifter
Huvudupphovsmän: Wesemann, Duane R., Portuguese, Andrew J., Magee, Jennifer M., Gallagher, Michael P., Zhou, Xiaolong, Panchakshari, Rohit A., Alt, Frederick W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2012
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427115/
https://ncbi.nlm.nih.gov/pubmed/22869756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210286109
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