Physiological role of the 3′IgH CBEs super-anchor in antibody class switching

IgH class switch recombination (CSR) replaces Cμ constant region (C(H)) exons with one of six downstream C(H)s by joining transcription-targeted double-strand breaks (DSBs) in the Cμ switch (S) region to DSBs in a downstream S region. Chromatin loop extrusion underlies fundamental CSR mechanisms inc...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Zhang, Xuefei, Yoon, Hye Suk, Chapdelaine-Williams, Aimee M., Kyritsis, Nia, Alt, Frederick W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826415/
https://ncbi.nlm.nih.gov/pubmed/33441485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024392118
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