Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities

Conventional chemotherapy not only kills tumor cells but also changes gene expression in treatment-damaged tissues, inducing production of multiple tumor-supporting secreted factors. This secretory phenotype was found here to be mediated in part by a damage-inducible cell-cycle inhibitor p21 (CDKN1A...

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Hlavní autoři: Porter, Donald C., Farmaki, Elena, Altilia, Serena, Schools, Gary P., West, Deborah K., Chen, Mengqian, Chang, Bey-Dih, Puzyrev, Anatoliy T., Lim, Chang-uk, Rokow-Kittell, Rebecca, Friedhoff, Lawrence T., Papavassiliou, Athanasios G., Kalurupalle, Swathi, Hurteau, Gregory, Shi, Jun, Baran, Phil S., Gyorffy, Balazs, Wentland, Mark P., Broude, Eugenia V., Kiaris, Hippokratis, Roninson, Igor B.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427077/
https://ncbi.nlm.nih.gov/pubmed/22869755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206906109
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