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Hepatic Immunosuppressive Effects of Systemically-Administered Novel Dextran-Methylprednisolone Prodrugs with Peptide Linkers in Rats
The hepatic immunosuppressive activities of two novel dextran prodrugs of methylprednisolone (MP) containing one (DMP1) or five (DMP5) amino acids as linkers were studied in rats. At various times (0–2 weeks) after intravenous administration of single 5-mg/kg (MP equivalent) doses of each prodrug or...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3426655/ https://ncbi.nlm.nih.gov/pubmed/22829462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23274 |
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