Attenuation of Acute Rejection in a Rat Liver Transplantation Model by a Liver-Targeted Dextran Prodrug of Methylprednisolone

BACKGROUND: The use of methylprednisolone (MP) and other corticosteroids for the treatment of acute liver allograft rejection is associated with severe toxicities in non-target tissues. Therefore, selective delivery of MP to the liver may improve its efficacy and alleviate its side effects. We inves...

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Hlavní autoři: Chimalakonda, Anjaneya P., Montgomery, Donald L., Weidanz, Jon A., Shaik, Imam H., Nguyen, Justin H., Lemasters, John J., Kobayashi, Eiji, Mehvar, Reza
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1483062/
https://ncbi.nlm.nih.gov/pubmed/16534468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/01.tp.0000177654.48112.b6
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