Liquid chromatography-tandem mass spectrometry for the determination of methylprednisolone in rat plasma and liver after intravenous administration of its liver-targeted dextran prodrug

A specific and sensitive liquid chromatography (LC)-tandem mass spectrometric method for quantitative determination of methylprednisolone (MP) in rat plasma and liver was developed and validated using triamcinolone acetonide as an internal standard. Liquid-liquid extraction using tert-butyl methyl e...

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Bibliographic Details
Main Authors: Zhang, Shuang-Qing, Thorsheim, Helen R., Penugonda, Suman, Pillai, Venkateswaran C., Smith, Quentin R., Mehvar, Reza
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709595/
https://ncbi.nlm.nih.gov/pubmed/19269263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2009.02.028
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