Synthesis and In Vitro Characterization of Novel Dextran-Methylprednisolone Conjugates with Peptide Linkers: Effects of Linker Length on Hydrolytic and Enzymatic Release of Methylprednisolone and its Peptidyl Intermediates

To control the rate of release of methylprednisolone (MP) in lysosomes, new dextran-MP conjugates with peptide linkers were synthesized and characterized. Methylprednisolone succinate (MPS) was attached to dextran 25 kDa using linkers with 1–5 Gly residues. The release characteristics of the conjuga...

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Bibliographic Details
Main Authors: Penugonda, Suman, Kumar, Anil, Agarwal, Hitesh K., Parang, Keykavous, Mehvar, Reza
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435384/
https://ncbi.nlm.nih.gov/pubmed/17853426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21161
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