Intravenous Administration of Adenoviruses Targeting Transforming Growth Factor Beta Signaling Inhibits Established Bone Metastases in 4T1 Mouse Mammary Tumor Model in an Immunocompetent Syngeneic Host

We have examined the effect of adenoviruses expressing soluble transforming growth factor receptorII-Fc (sTGFβRIIFc) in a 4T1 mouse mammary tumor bone metastasis model using syngeneic BALB/c mice. Infection of 4T1 cells with a non-replicating adenovirus, Ad(E1-).sTβRFc, or with two oncolytic adenovi...

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Xehetasun bibliografikoak
Egile Nagusiak: Zhang, Zhenwei, Hu, Zebin, Gupta, Janhavi, Krimmel, Jeffrey, Gerseny, Helen, Berg, Arthur, Robbins, John, Du, Hongyan, Prabhakar, Bellur, Seth, Prem
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424293/
https://ncbi.nlm.nih.gov/pubmed/22744210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2012.41
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