Systemic Delivery of a Novel Liver-Detargeted Oncolytic Adenovirus Causes Reduced Liver Toxicity but Maintains the Antitumor Response in a Breast Cancer Bone Metastasis Model

We are interested in developing oncolytic adenoviruses for the treatment of bone metastasis of cancer. A key limitation of systemic delivery of oncolytic adenovirus type 5 (Ad5) is that the majority of the virus is taken up by the liver, causing liver damage and systemic toxicity. Given that Ad5 hex...

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Detalhes bibliográficos
Main Authors: Zhang, Zhenwei, Krimmel, Jeffrey, Zhang, Zhiling, Hu, Zebin, Seth, Prem
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2011
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177947/
https://ncbi.nlm.nih.gov/pubmed/21480822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2011.003
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