Systemic Delivery of Oncolytic Adenoviruses Targeting Transforming Growth Factor-β Inhibits Established Bone Metastasis in a Prostate Cancer Mouse Model

We have examined whether Ad.sTβRFc and TAd.sTβRFc, two oncolytic viruses expressing soluble transforming growth factor-β receptor II fused with human Fc (sTGFβRIIFc), can be developed to treat bone metastasis of prostate cancer. Incubation of PC-3 and DU-145 prostate tumor cells with Ad.sTβRFc and T...

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Detalhes bibliográficos
Main Authors: Hu, Zebin, Gupta, Janhavi, Zhang, Zhenwei, Gerseny, Helen, Berg, Arthur, Chen, Yun Ju, Zhang, Zhiling, Du, Hongyan, Brendler, Charles B., Xiao, Xianghui, Pienta, Kenneth J., Guise, Theresa, Lee, Chung, Stern, Paula H., Stock, Stuart, Seth, Prem
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413899/
https://ncbi.nlm.nih.gov/pubmed/22551458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.040
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