Intravenous Administration of Adenoviruses Targeting Transforming Growth Factor Beta Signaling Inhibits Established Bone Metastases in 4T1 Mouse Mammary Tumor Model in an Immunocompetent Syngeneic Host

We have examined the effect of adenoviruses expressing soluble transforming growth factor receptorII-Fc (sTGFβRIIFc) in a 4T1 mouse mammary tumor bone metastasis model using syngeneic BALB/c mice. Infection of 4T1 cells with a non-replicating adenovirus, Ad(E1-).sTβRFc, or with two oncolytic adenovi...

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Hlavní autoři: Zhang, Zhenwei, Hu, Zebin, Gupta, Janhavi, Krimmel, Jeffrey, Gerseny, Helen, Berg, Arthur, Robbins, John, Du, Hongyan, Prabhakar, Bellur, Seth, Prem
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424293/
https://ncbi.nlm.nih.gov/pubmed/22744210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2012.41
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