Synthesis of Tetrazolo-Fused Benzodiazepines and Benzodiazepinones by a Two-Step Protocol Using an Ugi-Azide Reaction for Initial Diversity Generation

A two-step strategy for the synthesis of arrays of tricyclic tetrazolo-fused benzodiazepines and benzodiazepinones has been investigated. The protocol uses ortho-N-Boc phenylisocyanides and phenylglyoxaldehydes or ethyl glyoxylate in the 4-component Ugi-Azide reaction to afford MCR (Multi Component...

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Main Authors: Gunawan, Steven, Ayaz, Muhammad, De Moliner, Fabio, Frett, Brendan, Kaiser, Christine, Patrick, Nina, Xu, Zhigang, Hulme, Christopher
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423981/
https://ncbi.nlm.nih.gov/pubmed/22923851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2012.04.068
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