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Profiling the Dynamic Interfaces of Fluorinated Transcription Complexes for Ligand Discovery and Characterization
The conformationally dynamic binding surfaces of transcription complexes present a particular challenge for ligand discovery and characterization. In the case of the KIX domain of the master coactivator CBP/p300, few small molecules have been reported that target its two allosterically regulated bin...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3423543/ https://ncbi.nlm.nih.gov/pubmed/22725662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb3002733 |
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