Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes

Human rhinoviruses, the most important etiologic agents of the common cold, are messenger-active single-stranded monocistronic RNA viruses that have evolved a highly complex cascade of proteolytic processing events to control viral gene expression and replication. Most maturation cleavages within th...

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Main Authors: Matthews, D. A., Dragovich, P. S., Webber, S. E., Fuhrman, S. A., Patick, A. K., Zalman, L. S., Hendrickson, T. F., Love, R. A., Prins, T. J., Marakovits, J. T., Zhou, R., Tikhe, J., Ford, C. E., Meador, J. W., Ferre, R. A., Brown, E. L., Binford, S. L., Brothers, M. A., DeLisle, D. M., Worland, S. T.
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 1999
主題:
Colloquium Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC34232/
https://ncbi.nlm.nih.gov/pubmed/10500114
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