Conservation of Amino Acids in Human Rhinovirus 3C Protease Correlates with Broad-Spectrum Antiviral Activity of Rupintrivir, a Novel Human Rhinovirus 3C Protease Inhibitor

The picornavirus 3C protease is required for the majority of proteolytic cleavages that occur during the viral life cycle. Comparisons of published amino acid sequences from 6 human rhinoviruses (HRV) and 20 human enteroviruses (HEV) show considerable variability in the 3C protease-coding region but...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Antimicrob Agents Chemother
Egile Nagusiak: Binford, S. L., Maldonado, F., Brothers, M. A., Weady, P. T., Zalman, L. S., Meador, J. W., Matthews, D. A., Patick, A. K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology (ASM) 2005
Gaiak:
Antiviral Agents
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC547258/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15673742/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.49.2.619-626.2005
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