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Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes
Human rhinoviruses, the most important etiologic agents of the common cold, are messenger-active single-stranded monocistronic RNA viruses that have evolved a highly complex cascade of proteolytic processing events to control viral gene expression and replication. Most maturation cleavages within th...
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Główni autorzy: | , , , , , , , , , , , , , , , , , , , |
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Format: | Artigo |
Język: | Inglês |
Wydane: |
The National Academy of Sciences
1999
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC34232/ https://ncbi.nlm.nih.gov/pubmed/10500114 |
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