Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes

Human rhinoviruses, the most important etiologic agents of the common cold, are messenger-active single-stranded monocistronic RNA viruses that have evolved a highly complex cascade of proteolytic processing events to control viral gene expression and replication. Most maturation cleavages within th...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Matthews, D. A., Dragovich, P. S., Webber, S. E., Fuhrman, S. A., Patick, A. K., Zalman, L. S., Hendrickson, T. F., Love, R. A., Prins, T. J., Marakovits, J. T., Zhou, R., Tikhe, J., Ford, C. E., Meador, J. W., Ferre, R. A., Brown, E. L., Binford, S. L., Brothers, M. A., DeLisle, D. M., Worland, S. T.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1999
Matèries:	Colloquium Paper
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34232/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500114/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.20.11000
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