Conservation of Amino Acids in Human Rhinovirus 3C Protease Correlates with Broad-Spectrum Antiviral Activity of Rupintrivir, a Novel Human Rhinovirus 3C Protease Inhibitor

The picornavirus 3C protease is required for the majority of proteolytic cleavages that occur during the viral life cycle. Comparisons of published amino acid sequences from 6 human rhinoviruses (HRV) and 20 human enteroviruses (HEV) show considerable variability in the 3C protease-coding region but...

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Bibliografski detalji

Izdano u:	Antimicrob Agents Chemother
Glavni autori:	Binford, S. L., Maldonado, F., Brothers, M. A., Weady, P. T., Zalman, L. S., Meador, J. W., Matthews, D. A., Patick, A. K.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 2005
Teme:	Antiviral Agents
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC547258/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15673742/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.49.2.619-626.2005
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