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In Vitro Antiviral Activity and Single-Dose Pharmacokinetics in Humans of a Novel, Orally Bioavailable Inhibitor of Human Rhinovirus 3C Protease

(E)-(S)-4-((S)-2-{3-[(5-methyl-isoxazole-3-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-pent-4-ynoylamino)-5-((S)-2-oxo-pyrrolidin-3-yl)-pent-2-enoic acid ethyl ester (Compound 1) is a novel, irreversible inhibitor of human rhinovirus (HRV) 3C protease {inactivation rate constant (K(obs)/[I]) of 223,000...

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Main Authors: Patick, Amy K., Brothers, Mary A., Maldonado, Fausto, Binford, Susan, Maldonado, Oscar, Fuhrman, Shella, Petersen, Annkatrin, Smith, George J., Zalman, Leora S., Burns-Naas, Leigh Ann, Tran, Jonathan Q.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140523/
https://ncbi.nlm.nih.gov/pubmed/15917520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.6.2267-2275.2005
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