In Vitro Antiviral Activity of AG7088, a Potent Inhibitor of Human Rhinovirus 3C Protease

AG7088 is a potent, irreversible inhibitor of human rhinovirus (HRV) 3C protease {inactivation rate constant (k(obs)/[I]} = 1,470,000 ± 440,000 M(−1) s(−1) for HRV 14) that was discovered by protein structure-based drug design methodologies. In H1-HeLa and MRC-5 cell protection assays, AG7088 inhibi...

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Autors principals: Patick, A. K., Binford, S. L., Brothers, M. A., Jackson, R. L., Ford, C. E., Diem, M. D., Maldonado, F., Dragovich, P. S., Zhou, R., Prins, T. J., Fuhrman, S. A., Meador, J. W., Zalman, L. S., Matthews, D. A., Worland, S. T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC89498/
https://ncbi.nlm.nih.gov/pubmed/10508022
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