In Vitro Antiviral Activity of AG7088, a Potent Inhibitor of Human Rhinovirus 3C Protease

AG7088 is a potent, irreversible inhibitor of human rhinovirus (HRV) 3C protease {inactivation rate constant (k(obs)/[I]} = 1,470,000 ± 440,000 M(−1) s(−1) for HRV 14) that was discovered by protein structure-based drug design methodologies. In H1-HeLa and MRC-5 cell protection assays, AG7088 inhibi...

Descripció completa

Dades bibliogràfiques

Publicat a:	Antimicrob Agents Chemother
Autors principals:	Patick, A. K., Binford, S. L., Brothers, M. A., Jackson, R. L., Ford, C. E., Diem, M. D., Maldonado, F., Dragovich, P. S., Zhou, R., Prins, T. J., Fuhrman, S. A., Meador, J. W., Zalman, L. S., Matthews, D. A., Worland, S. T.
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 1999
Matèries:	Antiviral Agents
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89498/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10508022/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.10.2444
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!