BRAF inhibitor vemurafenib improves the antitumor activity of adoptive cell immunotherapy

Combining immunotherapy with targeted therapy blocking oncogenic BRAF(V600) may result in improved treatments for advanced melanoma. Here, we developed a BRAF(V600E)-driven murine model of melanoma, SM1, which is syngeneic to fully immunocompetent mice. SM1 cells exposed to the BRAF inhibitor vemura...

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Main Authors: Koya, Richard C., Mok, Stephen, Otte, Nicholas, Blacketor, Kevin J., Comin-Anduix, Begonya, Tumeh, Paul C., Minasyan, Aspram, Graham, Nicholas A., Graeber, Thomas G., Chodon, Thinle, Ribas, Antoni
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422880/
https://ncbi.nlm.nih.gov/pubmed/22693252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-2837
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