Carbonylation Induces Heterogeneity in Cardiac Ryanodine Receptor Function in Diabetes Mellitus

Heart failure and arrhythmias occur at 3 to 5 times higher rates among individuals with diabetes mellitus, compared with age-matched, healthy individuals. Studies attribute these defects in part to alterations in the function of cardiac type 2 ryanodine receptors (RyR2s), the principal Ca(2+)-releas...

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Hauptverfasser: Shao, Chun Hong, Tian, Chengju, Ouyang, Shouqiang, Moore, Caronda J., Alomar, Fadhel, Nemet, Ina, D'Souza, Alicia, Nagai, Ryoji, Kutty, Shelby, Rozanski, George J., Ramanadham, Sasanka, Singh, Jaipaul, Bidasee, Keshore R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422706/
https://ncbi.nlm.nih.gov/pubmed/22648972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.078352
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