Generation of transgene-free lung disease-specific human iPS cells using a single excisable lentiviral stem cell cassette

The development of methods to achieve efficient reprogramming of human cells while avoiding the permanent presence of reprogramming transgenes represents a critical step towards the use of induced pluripotent stem cells (iPSC) for clinical purposes, such as disease modeling or reconstituting therapi...

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Hauptverfasser: Somers, A., Jean, J.C., Sommer, C.A., Omari, A., Ford, C.C., Mills, J.A., Ying, L., Sommer Gianotti, A., Jean, J.M., Smith, B.W., Lafyatis, R., Demierre, M.F., Weiss, D.J., French, D.L., Gadue, P., Murphy, G.J., Mostoslavsky, G., Kotton, D.N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422663/
https://ncbi.nlm.nih.gov/pubmed/20715179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.495
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