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Genetic ablation of Adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model

OBJECTIVE: ADAMTS13 cleaves von Willebrand factor (VWF), thereby modulating thrombosis and inflammation. Low plasma ADAMTS13 activity is associated with cardiovascular events including myocardial and cerebral infarction. Here, we investigated the role of ADAMTS13 in the development of early atherosc...

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Bibliographic Details
Main Authors: Tohyama, Junichiro, Bauer, Robert C., Cao, Na Nora, Rader, Daniel J., Zheng, X. Long
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422623/
https://ncbi.nlm.nih.gov/pubmed/22652598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.247262
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